Fig. 3: Principal component analysis and differentially expressed genes in AKR1B10hi leiomyomas. | Oncogenesis

Fig. 3: Principal component analysis and differentially expressed genes in AKR1B10hi leiomyomas.

From: A novel uterine leiomyoma subtype exhibits NRF2 activation and mutations in genes associated with neddylation of the Cullin 3-RING E3 ligase

Fig. 3

a Thirteen AKR1B10hi leiomyomas and seven corresponding myometrium samples were analyzed together with a previously published dataset of 44 leiomyoma and 5 myometrium samples. Principal component analysis revealed that the AKR1B10hi samples cluster separately from leiomyomas of the MED12, HMGA2, and FH subtypes. Samples analyzed in this study are marked with sample identifiers. b AKR1B10 was significantly upregulated in AKR1B10hi and FH-deficient leiomyomas, but not in the other leiomyoma subtypes. c Deubiquitination gene UCHL1 was among the most uniquely upregulated genes in AKR1B10hi leiomyomas.

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