Fig. 2: High HPSE expression level is associated with poor prognosis of BRAF V600E-mutant CRC patients.

A Representative images of immunohistochemical staining for HPSE. B Kaplan–Meier survival curves in HPSE high and low groups of patients with BRAF V600E-mutant CRC. A log-rank test was used to calculate the P-value. Shaded regions around the curves indicate 95% confidence intervals. The number of patients at risk and censoring are presented below the survival curve. C Results of univariate Cox proportional hazard model presented as Hazard ratios (blocks in the center) and 95% confidence intervals (Whiskers of error bars). D Results of multivariate Cox proportional hazard model presented as Hazard ratios (blocks in the center) and 95% confidence intervals (Whiskers of error bars). E Results of survival analysis in different subgroups. Hazard ratios (blocks in the center) and 95% confidence intervals (Whiskers of error bars) were determined by univariate Cox regression. The reference level in each subgroup was HPSE low. Kaplan–Meier survival curves in the (F) left location subgroup and (G) pMMR subgroup. A log-rank test was used to determine P-value. Shaded regions around the curves indicate 95% confidence intervals. The number of patients at risk are presented below the survival curve. R survival package, survminer package, and forest package were used for survival analysis. HR hazard ratios; CI confidence intervals.