Fig. 5: SMC4 accelerates glioma cell tumorigenicity in vivo.

c Intracranial brain tumor xenograft model in nude mice; representative images of tumors from each group are shown. Hematoxylin–eosin (H&E, lower panel magnification, × 100) staining demonstrated that SMC4 overexpression induced the aggressive phenotype of glioma cells in vivo, whereas SMC4 suppression inhibited it.