Fig. 1: Overexpression of MYCN and deletion of CREBBP via hGFAP-cre induces malignant brain tumors in mice. | Oncogenesis

Fig. 1: Overexpression of MYCN and deletion of CREBBP via hGFAP-cre induces malignant brain tumors in mice.

From: The tumor suppressor CREBBP and the oncogene MYCN cooperate to induce malignant brain tumors in mice

Fig. 1

A Schematic drawing of hGFAP-cre::CrebbpFl/Fl::lsl-MYCN mice. B Kaplan–Meyer survival curves for the transgenic mouse model. hGFAP-cre (n = 75) vs hGFAP-cre::CrebbpFl/Fl::lsl-MYCN (n = 41). ****p < 0.0001, log-rank test. Area between dotted line: 95% CI. C Representative histological overview image of an adult hGFAP-cre::CrebbpFl/Fl::lsl-MYCN mouse brain. H&E, haematoxylin and eosin. Arrow marks the tumor. D–G High power images and immunohistochemistry (IHC: Ki67 (E), MYCN (F), CREBBP (G)) of the forebrain tumor. Scale bar corresponds to 2 mm (overview) and 50 μm (high power images).

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