Fig. 8: A proposed regulatory model showing how PDCD11 facilitates G2/M transition in colorectal cancer cells. | Oncogenesis

Fig. 8: A proposed regulatory model showing how PDCD11 facilitates G2/M transition in colorectal cancer cells.

From: Programmed cell death 11 modulates but not entirely relies on p53-HDM2 loop to facilitate G2/M transition in colorectal cancer cells

Fig. 8

A On one hand, PDCD11 recruits p53 to HDM2 for ubiquitination, thereby degrading p53 to upregulate CDK1 to help CRC cells pass G2/M checkpoints under normal conditions. On the other hand, PDCD11 upregulates CDC25C to dephosphorylate CDK1, leading to an accelerated G2/M transition and proliferation in a p53-independent manner. B In addition to upregulating CDC25C to dephosphorylate CDK1, PDCD11 turns to upregulate CDK1 independently of p53 to resist DDS-induced G2/M arrest.

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