Fig. 7: The clinical significance of the USP21/G3BP1 axis in ESCC patients. | Oncogenesis

Fig. 7: The clinical significance of the USP21/G3BP1 axis in ESCC patients.

From: USP21-mediated G3BP1 stabilization accelerates proliferation and metastasis of esophageal squamous cell carcinoma via activating Wnt/β-Catenin signaling

Fig. 7

A, B G3BP1 protein expression was determined using IHC in the ESCC samples (86 pairs). Representative IHC staining of G3BP1 with scale bars (A) and quantification for IHC scores (B) as displayed. C Spearman correlation analysis was performed to evaluate the association between USP21 and G3BP1 protein levels in 86 pairs of ESCC tumor tissues. Kaplan-Meier curves with log-rank test were conducted to evaluate OS and PFS rates between ESCC patients with simultaneously high USP21 and G3BP1 expression and those with low protein levels of USP21 and G3BP1 (D, E), those with low USP21 and high G3BP1 protein levels (F, G), or those with high USP21 and low G3BP1 expression (H, I). J The schematic diagram was created by Figdraw, which illuminates the regulatory mechanism of the USP21/G3BP1/Wnt/β-Catenin axis in ESCC malignant progression. The Wilcoxon matched-pairs signed rank test was performed in (B) while a log-rank test was used in (D–I). All P values and n-numbers as shown.

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