Fig. 2: YAP/TAZ delay RBM39 degradation and promote integrin, collagen, and FAK activation to be resistant to indisulam.
From: YAP/TAZ interacts with RBM39 to confer resistance against indisulam
a Western blot of WT and LATS1/2 KO CAL27 cells treated with indisulam at 0, 0.01, 0.05, 0.1, 0.5, and 1 μM for 24 h. b Western blot treated with E7820. c Western blot of WT and LATS1/2 KO CAL27 cells treated with indisulam at 1 μM, cycloheximide at 200 μg/mL, and MG132 at 10 μM for 8 h. d GO and KEGG pathway enrichment analysis of DEGs in WT CAL27 cells treated with DMSO or indisulam. e Heatmap of integrins and collagens expression. f Western blot of WT and LATS1/2 KO CAL27 cells. Cells were treated with indisulam at 1 μM for 24 h. Protein level of RBM39 was compared to WT CAL27 cells without indisulam, E7820, cycloheximide, or MG132 treatment (a–c, f).
