Fig. 4: LATS1/2 KO-driven YAP/TAZ activation confers resistance against indisulam in vitro and in vivo.
From: YAP/TAZ interacts with RBM39 to confer resistance against indisulam
a Cell viability of WT and LATS1/2 KO CAL27 cells. (N = 3). b Crystal violet staining of viable WT and LATS1/2 KO CAL27 cells treated with indisulam. c Crystal violet staining treated with E7820. d Average growth curves for WT and LATS1/2 KO CAL27 cells transplanted into athymic nude mice. The tumors were treated with indisulam for 6 days (N = 10 per group). e Summary of the mechanism. ANOVA with Tukey–Kramer post hoc test was used. Mean ± SEM (d); ****, P < 0.0001; **, P < 0.01.
