Fig. 6: Combination PI3K and STAT3 inhibitor treatment is effective against BCa models in vivo.
From: Combined Inhibition of PI3K and STAT3 signaling effectively inhibits bladder cancer growth
A Patient-derived xenograft tumors implanted into nude mice were randomized to DMSO, 10 mg/kg copanlisib, 4 mg/kg napabucasin, or the combination at the same doses in each cohort. Representative images (B) and quantification (C) of immunostaining for phosphorylated STAT3 and Ki-67 in Patient-derived xenograft was quantitatively measured three sections from every tumor tissue, Scale bar, 20 μm. Representative images (D) and quantification (E) of immunostaining for phosphorylated STAT3 and Ki-67 in BBN-induced tumor was quantitatively measured three sections from every tumor tissue, Scale bar, 20 μm. Data are presented as mean ± SD of independent samples with individual data points shown; P values were assessed by two-tailed Student t test in comparison with vehicle (DMSO) group (C, E, F); *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001.
