Fig. 4: “Disease and Functions” characterization.

We displayed selected entities for each “Disease and Functions” category, also described in tissue biomarkers meta-analysis: A cell death, signaling, and movement and B inflammatory response and organismal injury. The z-score value shows the modulation (upregulation for z-score greater than 2 and downregulation for z-score lower than −2) of each function with a significance of −log10 (P value) indicated by bubble colors (color scale of red and green). The size of bubbles depends on the number of biomarkers that overlap the described pathway. This bubble blot has been created using the values of “P value”, “z-score”, and “# of molecules” resulting from the functional analysis carried out by IPA software.