Fig. 7: DDR1-IN-1 combined with cisplatin shows synergistic efficacy in mouse xenografts. | Oncogenesis

Fig. 7: DDR1-IN-1 combined with cisplatin shows synergistic efficacy in mouse xenografts.

From: Collagen type IV alpha 6 promotes tumor progression and chemoresistance in ovarian cancer by activating the discoidin domain receptor 1 pathway

Fig. 7

A A2780/COL4A6 ovarian cancer xenografts treated with only DDR1-IN-1 at doses of 6.25 mg/kg and 12.5 mg/kg or combined with 2 mg/kg cisplatin. **P < 0.005, on day 28, DDR1-IN-1 12.5 mg/kg + CDDP 2 mg/kg vs. CDDP alone (P < 0.001) or varying doses of DDR1-IN-1 (6.25 mg/kg, P < 0.001; 12.5 mg/kg, P < 0.001). B Representative immunohistochemical photos of p-DDR1 and COL4A6 in ovarian tumor samples from mice treated with DDR1-IN-1 or vehicle controls. C Representative immunohistochemical photos of Ki-67 in ovarian tumor samples from mice treated with DDR1-IN-1 or vehicle controls. D A model illustrating the hypothetical role of COL4A6 regulation in ovarian cancer cells.

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