Abstract
Background
To determine how maternal obesity or gestational diabetes mellitus (GDM) affect infant body size and body composition during the first year of life.
Methods
Eighty three normal-weight (NW) women, 26 obese (OB) women, and 26 women with GDM were recruited during pregnancy. Infant body composition was determined by air-displacement plethysmography at 1 and 12 weeks, and anthropometric measurements made until 1 year of age.
Results
Girl infants born to OB women and women with GDM had a higher body-fat percentage (BF%) at 1 and 12 weeks of age than girls born to NW women. Girls had higher BF% than boys in OB and GDM groups only. Maternal HbA1c and fasting plasma glucose correlated with girl infant BF% at 1 week of age. Maternal weight at start of pregnancy correlated with birthweight in NW and OB groups, but not the GDM group. OB group infants showed greater BMI increases from 1 week to 1 year than both NW and GDM group infants.
Conclusion
Results show that both maternal glycaemia and obesity are determinants of increased early life adiposity, especially in girls, with glycaemic levels being more influential than maternal weight for infants born to women with GDM.
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Acknowledgements
The authors thank all participating mothers and infants and Aldina Pivodic for expert statistical guidance and analyses.
Funding
This work was supported by grants from the Swedish Research Council (12206), the Swedish Diabetes Association Research Foundation and the Swedish federal government LUA/ALF agreement for Sahlgrenska University Hospital.
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Andersson-Hall, U.K., Järvinen, E.A.J., Bosaeus, M.H. et al. Maternal obesity and gestational diabetes mellitus affect body composition through infancy: the PONCH study. Pediatr Res 85, 369–377 (2019). https://doi.org/10.1038/s41390-018-0248-9
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DOI: https://doi.org/10.1038/s41390-018-0248-9
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