Table 1 Characteristics of studies on the effect of an intervention aimed to increase physical activity in children with congenital heart disease.

From: Physical activity modification in youth with congenital heart disease: a comprehensive narrative review

Study

Subjects

Exercise intervention

Outcome

Results

Qualitya

 

n; age (mean ± SD), % girls

Cardiac diagnosis (n); additional inclusion criteria (if applicable)

      
 

Intervention

Control

  

Measure

Method of measurement

Timing of measurement

  

Dulfer et al.67 and Duppen et al.60

56; 15 ± 3 years, 24%

37; 16 ± 3 years, 30%

ToF (47), Fontan (44)

12-week standardized aerobic exercise training programme

Physical activity; active leisure time

5-day accelerometry; self-report questionnaire

Directly after intervention

Exercise training did not change time spent in PA or self-reported active leisure time in either ToF or Fontan patients

High

Fredriksen et al.61

55; 12.4 ± 1.5 years, 45%

38, age n/a, 50%

LVOTO (20), TGA (17), ASD/VSD (16), ToF (16), RVOTO (9), Fontan (6), other (9); physical fitness equal or poorer than peers

2-week training programme in a rehabilitation sport centre or a 5-month training programme near their own home twice a week

Exercise time

1–2-week activity tracker

1–2 weeks after intervention

Exercise time increased similarly between groups from 677 ± 151 to 708 ± 152 s/day in parallel with increase in peak oxygen uptake and ventilation

Low

Hedlund et al.62

30; 14.2 ± 3.2 years, 46.6%

25; 13.6 ± 3.5 years, 48.0%

Fontan

12-week, twice a week, 45 min, individualized endurance training programme near home

Exercise time

Self-report questionnaire

Directly after intervention, 1 year

In the intervention group, self-reported exercise time increased from 113.5 ± 66.1 at baseline to 168.3 ± 92.7 min/week. At 1-year follow-up, amount of exercise returned to baseline

Moderate

Klausen et al.63

81, 14.6 ± 1.3 years, 41.8% (of full cohort)

77, 14.6 ± 1.2 years, 41.8% (of full cohort)

CoA (52), TGA (35), ToF (21), AVSD (9) DORV (7), Fontan (6), TA (4), other (24)

52-week eHealth intervention delivering individually tailored text messages to encourage PA

Time in MVPA

6 day accelerometry, self-report questionnaire

Directly after intervention

Patients in the intervention group spent 40.3 ± 21.8 min/day in MVPA compared to 41.3 ± 22.9 min/day for controls (not significantly different). Assessments of PA by questionnaire yielded similar results

High

Longmuir et al.64

61; 9.1 years [IQR 7.7–10.5], 41%

Fontan

12-month, weekly parent-lead, home-based intervention to enhance PA, motor skill, fitness, and activity attitudes

MVPA

7-day accelerometry

At the start of intervention, 6 months, 12 months (end of intervention), 24 months

MVPA increased significantly by 6 months, decreased at 12 months and then increased again to 36 ± 31 min/week (p = 0.04) above baseline at 24 months

Moderate

Moons et al.65

25; 12 years (IQR 10.5–13], 28%

Fontan (6), ToF (4), TGA (3), other (12)

3-day multisports camp for children with CHD

Habitual PA

Self-report questionnaire

3 months after intervention

No differences observed in habitual PA scores

Low

Morrison et al.66

72; 15.3 ± 2.2 years, 33.3%

71; 15.9 ± 2.2 years, 46.5%

Acyanotic corrected CHD (61), minor CHD (39), cyanotic corrected (30), cyanotic palliated (13)

6-month, monthly motivational interview-style group sessions

MVPA, % meeting national UK PA recommendations (>60 min/day MVPA)

7-day accelerometry

Directly after intervention

Significant increase in MVPA from 28.4 ± 20.1 to 57.2 ± 32.2 min/day (p < 0.001) for the intervention group while MVPA remained the same in controls. Number of patients meeting the PA recommendation doubled from 14 to 29

High

Rhodes et al.47

15; 11.9 ± 2.2 years, 26.7%

18; 12.1 ± 2.5 years, 22.2%

Complex CHD; peak work rate and/or peak VO2 < 80% of predicted

12-week, twice a week, 1 h exercise sessions

Exercise frequency

Self-report questionnaire

1 year after intervention

Patients in the intervention group reported they exercised more frequently than the year before; the control subjects did not (p = 0.07 for between-group difference)

Low

  1. ASD atrial septal defect, AVSD atrioventricular septal defect, CHD congenital heart disease, CoA coarctation of the aorta, DORV double outlet right ventricle, LVOTO left ventricular outflow tract obstruction, MVPA moderate-to-vigorous physical activity, PA physical activity, RVOTO right ventricular outflow tract obstruction, TA tricuspid atresia, TGA transposition of the great arteries, ToF tetralogy of Fallot, VSD ventricular septal defect.
  2. aFor quality scoring, see Supplementary Table 2.