Abstract
Background
Tissue oximeters are not interchangeable. Two instruments with sensors dedicated to preterm infants—INVOS 5100C and Nonin SenSmart X-100—have not yet been compared.
Methods
By measuring cerebral oxygenation in ten preterm infants with spontaneous apneic episodes defined by pulse oximeter readings (SpO2) below 80%, as well as tissue oxygenation during vascular occlusion on the forearm of ten adults, simultaneously we compared performance in the hypoxic range.
Results
We found the mean conversion equations to be StO2,SenSmart X-100 = 0.34 × StO2,INVOS 5100C + 44.8% during apnea in infants and StO2,SenSmart X-100 = 0.59 × StO2,INVOS 5100C + 34.4% during vascular occlusion. The individual regressions displayed large and statistically significant variations in both infants and adults. In three infants the INVOS sensor showed very little reaction to decreases in SpO2.
Conclusions
These findings confirm that different NIRS devices give very different estimates when the oxygenation is low. The large variation when compared to SpO2 suggest that the sensor placement is very important in preterm infants.
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Change history
02 April 2020
A Correction to this paper has been published: https://doi.org/10.1038/s41390-020-0869-7
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Acknowledgements
We are thankful for the parents of the infants who decided to participate in the clinical investigation.
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B.A. conceptualized and designed the study, performed data collection and analysis, drafted and revised the manuscript, and approved the final manuscript as submitted. G.G. conceptualized and designed the study, performed data analysis, reviewed and revised the manuscript, and approved the final manuscript as submitted. S.H.-S. conceptualized and designed the study, performed data analysis, reviewed and revised the manuscript, and approved the final manuscript as submitted.
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Andresen, B., Greisen, G. & Hyttel-Sorensen, S. Comparison of INVOS 5100C and Nonin SenSmart X-100 oximeter performance in preterm infants with spontaneous apnea. Pediatr Res 87, 1244–1250 (2020). https://doi.org/10.1038/s41390-020-0752-6
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DOI: https://doi.org/10.1038/s41390-020-0752-6
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