Abstract
The 2019 Necrotizing Enterocolitis (NEC) Symposium expanded upon the NEC Society’s goals of bringing stakeholders together to discuss cutting-edge science, potential therapeutics and preventative measures, as well as the patient-family perspectives of NEC. The Symposium facilitated discussions and shared knowledge with the overarching goal of creating “A World Without NEC.” To accomplish this goal, new research to advance the state of the science is necessary. Over the last decade, several established investigators have significantly improved our understanding of the pathophysiology of NEC and they have paved the way for the next generation of clinician-scientists funded to perform NEC research. This article will serve to highlight the contributions of these young clinician-scientists that seek to elucidate how immune, microbial and nervous system dysregulation contributes to the pathophysiology of NEC.
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Acknowledgements
Publication of this article was sponsored by the Necrotizing Enterocolitis (NEC) Society, Patient-Centered Outcomes Research Institute, and National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health and Human Development.
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T.A.M., C.A.M., H.C., J.C., H.T., H.D., M.G. all made substantial contributions to the conception of the article, drafting the article, critical revisions and approval of the final version to be published.
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T.A.M. receives consulting fees from Onsite, LLC-Medical Consulting and Scioto-Medical Consulting, and receives grant support from Scioto. T.A.M. is also supported by the National Institutes of Health, the Koret Foundation, The George H. Clowe’s Memorial Research Career Development Award, and the Department of Surgery at the Indiana University School of Medicine. C.A.M. is supported by the National Institutes of Health, National Institute of Child Health and Human Development (NICHD) Pediatric Loan Repayment Program, American Surgical Association, Society for Surgery of the Alimentary Tract, Kaul Pediatric Research Institute, University of Alabama Department of Surgery. H.C. is supported by the National Institutes of Health, Presbyterian Health Foundation, and the Division of Neonatology at the Oklahoma University Health Sciences. J.C. is the founder and Director of The NEC Society, sponsor of the supplement. M.G. is supported by the National Institutes of Health, March of Dimes Foundation, the St. Louis Children’s Hospital Foundation, the Children’s Discovery Institute of Washington University and St. Louis Children’s Hospital, and the Department of Pediatrics at Washington University School of Medicine, St. Louis. H.T. and H.D. declare no competing interests.
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Markel, T.A., Martin, C.A., Chaaban, H. et al. New directions in necrotizing enterocolitis with early-stage investigators. Pediatr Res 88 (Suppl 1), 35–40 (2020). https://doi.org/10.1038/s41390-020-1078-0
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DOI: https://doi.org/10.1038/s41390-020-1078-0
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