Fig. 1: SAG administration following tMCAO improves brain volume.
From: Neuroprotective effects of Sonic hedgehog agonist SAG in a rat model of neonatal stroke
a Diagram of transient middle cerebral artery occlusion (tMCAO) injury region in a coronal section of a rat brain, and experimental timeline for tMCAO and volume/cell fate analysis. Contra contralateral/uninjured hemisphere, Ipsi ipsilateral/injured hemisphere. b Representative images of coronal sections from rat brains 2 weeks post-tMCAO or sham surgery, at P24. c Quantification of brain volume following surgery and treatment, showing ratio of injured (ipsilateral) and uninjured (contralateral) hemispheric volumes. d Quantification of corpus callosum volume following surgery and treatment. For quantification, mean ± SEM; **p < 0.01 and ***p < 0.001 vs Sham+Veh, #p < 0.05 vs tMCAO+SAG; one-way ANOVA with Dunnett’s test. Veh injection of vehicle solution (0.85% saline solution).
