Fig. 6: SAG shows improvements in behavioral tests.
From: Neuroprotective effects of Sonic hedgehog agonist SAG in a rat model of neonatal stroke
a Experimental timeline for surgery, treatment, and behavioral tests for long-term neurobehavioral outcome. b Quantification of gross sensorimotor function between groups as assessed by forelimb preference in the Cylinder Rearing test. c Quantification of Novel Object Recognition test. d Quantification of ipsilateral-to-contralateral ratio of hemispheric brain volume. e Quantification of ipsilateral-to-contralateral ratio of corpus callosum volume. f Representative images of coronal sections from rat brains 2 months post-tMCAO or sham surgery. *p < 0.05, ***p < 0.001, ****p < 0.0001 vs Sham+Veh; #p < 0.05 vs tMCAO+SAG, one-way ANOVA with Tukey’s multiple comparisons test.
