Table 1 Summary of cases with and without abnormal mammillary body (MB) signal across sites.

From: Mammillary body injury in neonatal encephalopathy: a multicentre, retrospective study

Centre

Number of cases with normal MB signal

Number of cases with abnormal MB signal

Grade of neonatal encephalopathy I/II/III/NA

Pattern of injury normal/watershed/BGT/NT

  

Cases with normal MB signal

Cases with abnormal MB signal

Cases with normal MB signal

Cases with abnormal MB signal

Leiden

% within the MB group

% of all cases in the subgroup

75

61 (44.9%)

36/24/14/1

48%/32%/19%/1%

59%/55%/48%/50%

25/20/15/1

41%/33%/24%/2%

41%/45%/52%/50%

51/6/13/5

68%/8%/17%/7%

58%/66%/59%/29%

37/3/9/12

60%/5%/15%/20%

42%/33%/41%/71%

Genoa

% within the MB group

% across subgroup

52

31 (37.3%)

11/34/5/2

21%/65%/10%/4%

85%/61%/42%/100%

2/22/7/0

6%/71%/23%/0%

15%/39%/58%/0%

32/10/5/5*

62%/19%/10%/10%

24%/67%/42%/33%

9/5/7/10*

29%/16%/23%/33%

22%/33%/58%/67%

Combined

% within MB group

% across subgroup

127

92 (41.6%)

47/58/19/3

37%/46%/15%/2%

64%/58%/46%/75%

27/42/22/1

29%/46%/24%/1%

36%/42%/54%/25%

83/16/18/10**

65%/13%/14%/8%

64%/67%/53%/31%

46/8/16/22**

50%/9%/17%/24%

36%/33%/47%/69%

  1. NA: Could not be assessed due to high dose of sedatives. Pattern of injury: no abnormalities (normal), damage into the watershed areas, damage predominantly to the deep grey matter, that is, basal ganglia/thalamus (BGT), and severe brain damage, that is, near-total brain injury (NT).
  2. *P = 0.007 MB abnormalities vs no MB abnormality (Genoa, χ2).
  3. **P = 0.003 normal/watershed vs BGT/NT (Combined, χ2).