Fig. 1: Schematic description of the study and study cohort.
From: Blood protein profiles related to preterm birth and retinopathy of prematurity
a The cohort consisted of 14 extremely preterm infants (six females) born before 28 weeks of gestation in Gothenburg, Sweden. Blood samples were centrifuged to serum and levels of 448 unique protein targets in each sample were determined using the proximity extension assay technique. Clinical variables were integrated with the serum protein profiles. b Blood samples were collected at birth, after 1, 2, and 4 weeks postnatal age (PNA), and weeks 32, 36, and 40 postmenstrual age (PMA)). In total, 88 samples from 14 individuals were analyzed. The gestational ages varied from 22.9 to 27.6 weeks. Seven infants had severe retinopathy of prematurity (ROP) defined as stage 3 or type 1 ROP. Three had mild-to-moderate ROP defined as stages 1 and 2 and four had no signs of ROP.
