Table 1 Apnea and arousal definitions used in the current study.

From: Caffeine is a respiratory stimulant without effect on sleep in the short-term in late-preterm infants

Apnea

Definition

Duration

Central apnea

Apnea with no breathing movements

Pause in breathing lasting: >2 breathing cycles and ≥4 s

Obstructive apnea

Apneas with breathing movements but no airflow

All obstructive pauses of breathing

Mixed apnea

Apneas commencing as central but showed obstructive respiratory movements

All mixed apneas

Apnea of prematurity

Apnea with:

Heart rate decrease to <100 beats per minute, or drop in SpO2 to <80%, or apnea length of >20 s

 

Arousal

Definition

Duration

Arousal

A sustained increase in chin and diaphragm EMG from baseline recording excluding sucking of the dummy, or

gross body movements causing artefacts in ECG, EEG, respiratory signal

≥3 s

Apnea arousal

An arousal appearing during an apnea, or within 5 s after the end of an apnea

≥3 s

Long arousal or awakening

Same as arousal

≥15 s

  1. EMG electromyogram, ECG electrocardiogram, EEG electroencephalogram.