Fig. 1: Pathophysiology, phases of injury, and therapeutic windows for present and future neuroprotective interventions in term newborns.
From: Neuroprotective therapies in the NICU in term infants: present and future
Earliest phases of injury are targeted by interventions, including therapeutic hypothermia, acute neuroprotective bundles, and melatonin. Neuroplasticity bundles, erythropoietin, and stem cell therapies aim to reduce injury during the later phases. Improved seizure management offers neuroprotection throughout all stages of injury.
