Fig. 4: Antigenic changes in amino acid residues of VP7 epitopes.
From: Vaccine evaluation and genotype characterization in children infected with rotavirus in Qatar
a Alignment of amino acid residues in VP7 antigenic sites of sequenced RV viruses against Rotarix and RotaTeq vaccines’ strains. Antigenic sites of VP7 are distributed in three main epitopes (7-1a, 7-1b, and 7-2). Residues that are different from strains in both Rotarix® and RotaTeq® are highlighted in yellow, residues that are different from the strains in RotaTeq® are highlighted in green, and residues that are different from strains in Rotarix® are highlighted in blue. Amino acid residues known to mediate escape from neutralization by mAbs are indicated by an asterisk (*). b Three-dimensional representation of amino acid substitutions detected in VP7 protein of RV strains. 3D structure of the VP7 monomer (gray color). Antigenic epitopes are colored in blue (7-1a), lime green (7-1b), and light pink (7–2). Surface-exposed residues that differ between circulating strains in Qatar and the strains contained in Rotarix or RotaTeq are shown in red color.
