Fig. 5: Antigenic changes in amino acid residues of VP4 epitopes.
From: Vaccine evaluation and genotype characterization in children infected with rotavirus in Qatar
a Alignment of amino acid residues in VP4 antigenic sites of RV strains against Rotarix and RotaTeq vaccines’ strains. Antigenic sites of VP4 are distributed in four main epitopes (8-1, 8-2, 8-3, and 8-4). Residues that are different from strains in both Rotarix® and RotaTeq® are highlighted in yellow, residues that are different from the strains in RotaTeq® are highlighted in green, and residues that are different from strains in Rotarix® are highlighted in blue. Amino acid residues known to mediate escape from neutralization by mAbs are indicated by an asterisk (*). b Three-dimensional representation of amino acid substitutions detected in VP4 protein of RV strains. 3D structure of the VP4 monomer (gray color). Antigenic epitopes are colored in blue (8-1), lime green (8-2), light pink (8-3), and orange (8-4). Surface-exposed residues that differ between circulating strains in Qatar and the strains contained in Rotarix or RotaTeq are shown in red color.
