Table 1 Baseline clinical characteristics of the study population.

From: Reduction in regulatory T cells in preterm newborns is associated with necrotizing enterocolitis

 

Cases

Controls

 

NEC

Overall

FI

FT

Number

6

52

23

29

Prenatal characteristics

 GA, weeks

31.17 ± 1.47

32.06 ± 2.43

30.70 ± 2.85

33.14 ± 1.30**

 GA ≤28, weeks

1 (16.7)

5 (9.6)

5 (9.6)

0 (0.0)

 Twins, N (%)

3 (50)

36 (69.2)

16 (69.5)

20 (60.9)

 IUGR, N (%)

2 (33.3)

11 (21.6)

6 (27.3)

5 (17.2)

 Cesarean section, N (%)

5 (83.3)

49 (94.2)

23 (100)

26 (89.7)

 Mother’s age >35 years old, N (%)

2 (40)

17 (34)

8 (38.1)

9 (31.0)

 Hypertension, N (%)

0 (0)

5 (9.8)

3 (13.6)

2 (6.9)

 Hypothyroidism, N (%)

0 (0)

10 (19.6)

5 (22.7)

5 (17.2)

 Gestational diabetes, N (%)

0 (0)

11 (21.6)

7 (31.8)

4 (13.8)

 Antenatal corticosteroidsa, N (%)

4 (80)

36 (72)

16 (72.7)

20 (71.4)

 Uterine arteries flowmetry alteration, N (%)

0 (0)

6 (12)

3 (14.3)

3 (10.3)

Postnatal characteristics

 Female sex, N (%)

4 (66.7)

21 (40.4)

7 (30.4)

14 (48.3)

 Small for gestational age, N (%)

1 (16.7)

11 (21.2)

5 (21.7)

6 (20.7)

 BW, N (%)

1310 ± 681

1650 ± 503

1413 ± 485

1837 ± 440**

 BW ≤1000, g

2 (33.3)

6 (75)

5 (21.7)

1 (3.4)

 pH on cord blood

7.258 ± 0.064

7.270 ± 0.776

7.254 ± 0.101

7.281 ± 0.055

 Start of EN, DOL

3.60 ± 4.099

2.02 ± 6.629

3.95 ± 9.84

0.55 ± 0.78**

 Duration of PN, DOL

25.00 ± 16.73*

10.17 ± 15.47

20.48 ± 18.59

2.00 ± 2.87**

 Full enteral feeding, DOL

26.50 ± 16.42*

11.53 ± 15.57

22.45 ± 18.56

3.24 ± 3.12**

 Breast milk from 0 to 7 DOL, ml/die

92.50 ± 171.9

99.36 ± 191.5

54.67 ± 147.1

132.89 ± 215.48

  1. Data were expressed as mean ± standard deviation when not specified.
  2. FI feeding intolerance, FT feeding tolerance, GA gestational age, IUGR intrauterine growth restriction, BW birth weight.
  3. *p < 0.001 NEC versus controls (overall); **p < 0.001 NEC versus FT.
  4. aAn intramuscular steroids cycle in two doses of 12 mg over a 24-h period.