Table 2 Clinical characteristics, diagnoses, outcomes of neonates with seizures.
Baby | Gestation (weeks) | Respiratory status at time of seizure | Seizure burden | Clinical seizure semiology | Laterality | Anti seizure medication used* | Muscle paralysis | Diagnosis(**) | MRI finding (***) | Outcome and neurological exam at discharge | |
|---|---|---|---|---|---|---|---|---|---|---|---|
ventilated | FiO2 | Â | |||||||||
1 | 38 | Yes | 100% | High | No clinical seizures | Right | Ph,Md | no | HIE | Acute ischemic change within the cortex of both cerebral hemispheres | Alive, normal |
2 | 38 | Yes | 100% | High | Left arm twitching | Bilateral | Ph, Py, Md | yes | HIE | Not done | Died |
3 | 40 | Yes | 21% | High | Left arm and leg clonic jerking | Bilateral | Ph, Py, Md | no | Perinatal Stroke | Bilateral ischemic changes of the left MCA territory with ischemic change within the left PLIC | Alive, central hypotonia with significant head lag |
4 | 41 | Yes | 21% | Low | Rhythmic jerking of all four limbs | Bilateral | Ph | no | HIE | Normal | Alive, normal |
5 | 38 | Yes | 100% | High | Extensor posturing of right arm and cycling movements | Bilateral | Ph | no | HIE | Severe hypoxic ischemic injury of bilateral basal ganglia, thalami and PLIC | Alive, tube feeds |
6 | 39 | Yes | 21% | High | Left arm twitching with desaturations | Right | Ph | no | HIE | Normal | Alive, normal |
7 | 36 | Yes | 21% | Low | Clonic jerks in arms | Bilateral | Ph, Md | no | HIE | Severe hypoxic ischemic injury of bilateral basal ganglia, thalami, PLIC, optic tracts | Alive, central hypotonia with significant head lag |
8 | 40 | No | 21% | High | Left sided arm and leg → generalisation | Bilateral | Ph,Py,Md | no | IVH | Moderate volume intraventricular hemorrhage with early hydrocephalus | Alive, normal |
9 | 41 | Yes | 100% | High | Tonic jerks left upper limb | Right | Ph. Md | yes | Perinatal Stroke | Encephalomalacia - distribution suggestive of right MCA infarction | Alive, tone abnormalities at discharge |
10 | 37 | Yes | 100% | High | All four limbs - rhythmic jerking | Bilateral | Ph,Py,Md,Lt | yes | ARPKD | Severe global ischemic changes | Died |
11 | 38 | Yes | 30% | High | All four limbs - rhythmic twitching and abnormal posturing | Bilateral | Ph, Md, Py | no | HIE, hypoglycemic | Severe white matter changes bilaterally | Alive, abnormal tone and movements at discharge and needed NG feeds |
