Fig. 4: Comparison of perfusion parameters in the whole brain by days on the EXTEND circuit where early, intermediate, and late examinations are ≤ 4, 5–8, and ≥ 9 days on circuit, respectively.

Significant differences in a Microvascular flow velocity (MFV) b transit time and c microvascular blood flow (MBF) were demonstrated at later time points (≥9 days on circuit) with no statistically significant differences observed between hypoxic and control animals at earlier or intermediate time points.