Table 2 The biochemical results before and after treatment of patients in different groups.
From: Long-term follow-up of Chinese patients with methylmalonic acidemia of the cblC and mut subtypes
C3 | C3/C2 | uMMA | uMCA | Hcy | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
(0.40∼4.00 μmol/L) | (0.03∼0.20) | (0.0∼4.0 mmol/mol creatinine) | (0.0∼0.8 mmol/mol creatinine) | (0.0∼15 μmol/L) | |||||||||||
Before treatment | After treatment | p1 | Before treatment | After treatment | p1 | Before treatment | After treatment | p1 | Before treatment | After treatment | p1 | Before treatment | After treatment | p1 | |
Overall | 7.13 (4.87–10.41) | 3.43 (2.2–5.73) | <0.0001 | 0.6 (0.4–0.91) | 0.14 (0.081–0.23) | <0.0001 | 114.3 (40.47–286.40) | 7.2 (2.23–22.51) | <0.0001 | 3.13 (1.29–7.75) | 0.79 (0–1.9) | 0.0001 | 88.4 (51.09–148.9) | 35.65 (23.6–48) | <0.0001 |
Subtypes | |||||||||||||||
cblC | 6.68 (4.63–9.52) | 3.11 (2.02–4.81) | <0.0001 | 0.58 (0.39–0.9) | 0.12 (0.08–0.18) | <0.0001 | 95.25 (37.00–237.20) | 5.6 (1.89–15.38) | <0.0001 | 2.7 (1.1–5.79) | 0.63 (0–1.42) | <0.0001 | 102.3 (65–162) | 36.5 (25–49) | <0.0001 |
mut | 9.82 (6.34–15.48) | 12.75 (4.79–24.46) | 0.0089 | 0.64 (0.47–0.95) | 0.52 (0.24–0.74) | <0.0001 | 246 (98.09–558.30) | 116.6 (12.21–409.6) | <0.0001 | 6.85 (2.26–16.55) | 2.93 (0.85–6.75) | <0.0001 | |||
p2 | <0.0001 | <0.0001 | 0.027 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | |||||||
NBS | |||||||||||||||
Y(cblC) | 6.78 (4.86–9.37) | 2.70 (1.72–4.12) | <0.0001 | 0.57 (0.36–0.87) | 0.1 (0.06–0.15) | <0.0001 | 82.80 (32.40–207.10) | 4.35 (1.15–10.53) | <0.0001 | 2.6 (1.12–5.54) | 0.44 (0–1.16) | <0.0001 | 105 (66.65–173.2) | 33.53 (22.2–44.73) | <0.0001 |
N(cblC) | 6.53 (4.46–9.66) | 3.47 (2.38–5.21) | <0.0001 | 0.58 (0.39–0.91) | 0.14 (0.1–0.21) | <0.0001 | 103.5 (36.29–258.40) | 7.14 (2.78–20.00) | <0.0001 | 2.77 (1–5.92) | 0.8 (0–1.67) | <0.0001 | 97.12 (63.28–146.7) | 38.7 (26.6–52.9) | <0.0001 |
Y(mut) | 7.49 (4.91–11.46) | 6.68 (2.96–16.85) | 0.78 | 0.57 (0.33–0.85) | 0.30 (0.14–0.69) | <0.0001 | 127 (36.48–301.80) | 27.79 (6.77–208.4) | <0.0001 | 4 (1.52–12.19) | 1.6 (0.44–4.36) | <0.0001 | |||
N(mut) | 11.49 (7.73–18.51) | 18.25 (8.35–27.14) | 0.0046 | 0.71 (0.51–1.02) | 0.59 (0.38–0.78) | <0.0001 | 321.50 (152.5–734.3) | 211.90 (48.94–617.00) | 0.0009 | 8.615 (3.69–19.48) | 4.4 (1.475–9.93) | 0.0008 | |||
p3 | >0.9999 | <0.0001 | >0.9999 | <0.0001 | 0.43 | <0.0001 | >0.9999 | <0.0001 | 0.16 | <0.0001 | |||||
p4 | <0.0001 | <0.0001 | 0.0034 | <0.0001 | <0.0001 | 0.0003 | 0.037 | 0.0005 | |||||||
p5 | 0.21 | <0.0001 | >0.9999 | <0.0001 | 0.12 | <0.0001 | 0.027 | <0.0001 | |||||||
p6 | <0.0001 | <0.0001 | 0.001 | 0.0004 | <0.0001 | 0.0008 | <0.0001 | 0.0007 | |||||||
