Table 5 Regression analyses between ΔTSH and change in listed cardiovascular risk markers as dependent variables over an average follow-up time of 1.7 ± 0.8 years in children and adolescents with obesity (n = 100).

	Model 1		Model 2		Model 3		Model 4
	B	p	B	p	B	p	B	p
Δ BMI-SDS	0.05	0.12	0.05	0.11	0.05^a	0.11^a	0.04^a	0.19^a
Δ total-cholesterol (mmol/L)	0.11	0.02	0.11	0.02	0.11	0.02	0.10	0.03
Δ LDL (mmol/L)	0.10	0.02	0.10	0.02	0.09	0.02	0.08	0.04
Δ HDL (mmol/L)	0.00	0.75	0.00	0.85	0.01	0.70	0.01	0.69
Δ LDL/HDL	0.15	<0.01	0.15	<0.01	0.13	<0.01	0.12	<0.01
Δ Triglycerides (mmol/L)	0.13	<0.01	0.13	<0.01	0.12	<0.01	0.12	<0.01
Δ Fasting glucose (mmol/L)	−0.02	0.53	−0.02	0.59	−0.02	0.55	−0.01	0.72
Δ 2 h OGTT glucose (mmol/L)^b	0.19	0.31	0.18	0.33	0.15	0.42	0.16	0.41
Δ HbA1c (mmol/L)	0.34	0.17	0.31	0.21	0.23	0.36	0.29	0.24
Δ HOMA-IR^c	−0.84	0.19	−0.90	0.16	−1.1	0.09	−1.0	0.11

Statistically significant associations in bold.
Model 1: Univariate model with ΔTSH as dependent and listed cardiovascular risk factor as independent variable.
Model 2: adjusted for age and sex.
Model 3: adjusted for age, sex, and ΔBMI SDS.
Model 4: adjusted for age, sex, ΔBMI SDS and ΔT4.
^aRegression model not including ΔBMI SDS as dependent variable.
^bn = 58.
^cn = 61.

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