Table 3 Measures, sample collection and analyses by assessment point
T0 | T1 | T2 | T3 | T4 | |
|---|---|---|---|---|---|
Parental Assessments: Demographics, TSE patterns; TSE-related illnesses and visits | ✓ | ✓ | ✓ | ||
EMR Review: TSE-related: past medical history, diagnoses, PED/UC visits, and hospitalizations | ✓ | ✓ | ✓ | ||
Saliva: Marker of overall TSE - Cotinine | ✓ | ✓ | ✓ | ||
Hand wipes: Marker of THS pollution in the environment - Nicotine | ✓ | ✓ | ✓ | ||
Silicone Wristbands: Marker of Tobacco Smoke Pollution in the environment - Nicotine | ✓ | ✓ | |||
Urine: Markers of TSE and THS – Cotinine and NNAL | ✓ | ✓ | ✓ | ||
Saliva: Markers of immune response - Cytokines IL-8, IL-10, IL-1β, and TNF-α | ✓ | ✓ | ✓ | ||
Urine: Oxidative stress biomarkers: 8-isoprostane | ✓ | ✓ | ✓ | ||
Pulmonary Function Tests: FVC, FEV1 (age >5) | ✓ | ✓ | |||
Dust: THS Pollution- Nicotine | ✓ | ✓ |
