Fig. 3: Biophysical profile of immune cells of full-term and preterm babies.
From: Whole blood biophysical immune profiling of newborn infants correlates with immune responses
a Samples from two clinical cohorts corresponding to full term babies (n = 8) and preterm neonates (n = 16) were profiled using the custom microfluidic assay deployed within the NICU for the comparative profiling of immune biophysical properties. b BLIPI immune markers of size (S) and deformability (D) for the two cohorts are shown in a heatmap in a normalized scale from 0 to 1. One preterm infant developed bacterial sepsis and is highlighted in orange. c An unsupervised UMAP representation of the BLIPI immune data showing various clusters for full-term and preterm cohort with a single sepsis data point represented in orange. d A volcano plot illustrating the fold-change versus p-value significance with the dotted line representing boundary of significance. Selected immune profiles of interest are highlighted in darker shade of blue and labelled. e The labelled BLIPI markers are shown in box plots with the normalized auxiliary unit values. An independent two-tailed Student t test was performed for the two cohorts with p < 0.05, 0.01, 0.001 and 0.001 represented by *, **, *** and **** respectively.
