Fig. 2: Representative H&E-stained microphotographs of the sensorimotor cortex from female and male piglets showing dead cells (arrows), with diffuse edematous matrix and hypodense neuropil (more relevant in males). | Pediatric Research

Fig. 2: Representative H&E-stained microphotographs of the sensorimotor cortex from female and male piglets showing dead cells (arrows), with diffuse edematous matrix and hypodense neuropil (more relevant in males).

From: Sex dimorphism in brain cell death after hypoxia-ischemia in newborn piglets

Fig. 2

Original magnification ×400. Scale bar: 100 μm. Graphs: a Averaged number of dead cells per mm2 (pooled across regions and bregma 0/−2.0 levels) from females and males. The overall number of dead cells per mm2 was significantly (Unpaired t-test, **p < 0.01) higher in males versus females. AVG average. b Quantitative results of regional cell death between females and males. cTEX cingulate cortex, sTEX sensorimotor cortex, PvWM periventricular white matter, CDT caudate nucleus, THAL thalamus. Unpaired t-test for all regions but PvWM, analyzed by Mann-Whitney. *p < 0.05 or **p < 0.01 or ****p < 0.0001 vs females.

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