Table 3 Monthly percent changes* (MPCs) with associated 95% confidence intervals (CIs) for the comparison of the rates of ventilator- and oxygen-free days between periods of bundle implementation

From: Reducing NICU ventilator days by preventing fluid overload with the CAN-U-P-LOTS standardized bundle

 

Pre-bundle (Jan 2023–July 2023)

Post-bundle (September 2023–April 2024)

Difference between eras

 

Days/Total

MPC (95% CI)

Days/Total

MPC (95% CI)

p-value

Ventilator-free

\(\frac{{{\mathrm{3732}}}}{{{\mathrm{6619}}}}\,(56 \%)\)

−3.3 (−5.0, −1.6) p = 0.0002

\(\frac{{{\mathrm{5592}}}}{{{\mathrm{8335}}}}\,(67 \% )\)

4.0 (2.7, 5.3) p < 0.0001

p < 0.0001

Oxygen-free

\(\frac{{{\mathrm{1807}}}}{{{\mathrm{6619}}}}\,(27 \%)\)

0.0 (−0.04, 4.5) p = 0.9990

\(\frac{{{\mathrm{2603}}}}{{{\mathrm{8335}}}}\,(31 \% )\)

7.1 (3.5, 10.7) p < 0.0001

p = 0.0150

  1. * Estimated from a negative binomial regression using patient days within a given month as the model offset.