Fig. 4: Defective lymphopoiesis in the murine neonatal liver during PIA.
From: Immune landscape in liver of neonatal mice with phlebotomy-induced anemia
a Volcano plot showing differentially expressed genes (DEGs) of B-cell clusters derived from the liver between control and anemic groups. Genes with average log2 fold change >0.2 and −log10 (P value-adjust) >2 are plotted in red; others are blue. b Heat map showing the comparison between top-up- and downregulated genes in the B cell cluster between control and anemia. c Gene ontology enrichment analysis of B cells showed significantly enriched activated and suppressed pathways. d GSEA enrichment score curves of major suppressed pathways in anemic liver-derived B cell clusters. e Volcano plot showing DEGs of T-cell cluster derived from the liver between the control and anemic groups. Genes with average log2 fold change >0.2 and −log10 (P value-adjust) >2 are plotted in red; others are blue. f Heat map showing the comparison between top up- and downregulated genes in the T-cell cluster between control and anemia. g Gene ontology enrichment analysis of the T-cell cluster showed significantly enriched activated and suppressed pathways. h GSEA enrichment score curves of major pathways in the T-cell cluster derived from anemic liver. Specific details about (a–h) are as presented for monocyte clusters in Fig. 3a-d.
