Table 2 Growth outcomes by maternal inflammatory response (MIR).

From: Histologic chorioamnionitis and fat mass accretion in infants born preterm

 

Total (n = 376)

MIR none (n = 271)

MIR stage 1 (n = 19)

MIR stage 2 (n = 58)

MIR stage 3 (n = 28)

p value

Body composition at term-equivalent agea

 Fat mass, kg

0.33 (0.24–0.44)b

0.32 (0.23–0.42)b

0.34 (0.23–0.46)b

0.37 (0.29–0.45)b

0.45 (0.34–0.66)b

<0.0001

 Body fat percentage, %

14.9 ± 4.8c

14.4 ± 4.8c

14.0 ± 5.5c

16.2 ± 4.1c

18.3 ± 4.4c

<0.0001

 Fat mass z score

0.78 ± 1.10c

0.63 ± 1.10c

0.84 ± 1.11c

1.18 ± 0.93c

1.34 ± 1.05c

0.0001

 Body fat percentage z score

1.39 ± 1.17c

1.25 ± 1.17c

1.17 ± 1.27c

1.77 ± 1.01c

2.08 ± 1.00c

0.0001

 Mid-upper arm circumference, cm

8.8 (8.0–9.3)b

8.6 (8.0–9.1)b

8.8 (8.3–9.0)b

8.8 (8.0–9.3)b

10.0 (9.0–10.3)b

0.0353

Anthropometric growth ratesd

 Change in weight z score

−0.95 ± 0.59c

−0.90 ± 0.55c

−0.91 ± 0.59c

−1.02 ± 0.58c

−1.31 ± 0.87c

0.0030

 Change in length z score

−1.29 ± 0.93c

−1.23 ± 0.84c

−1.36 ± 1.10c

−1.44 ± 0.96c

−1.59 ± 1.38c

0.1189

 Change in head circumference z score

−0.85 (−1.39 to −0.24)b

−0.84 (−1.41 to −0.22)b

−0.65 (−1.01 to 0.17)b

−0.82 (−1.30 to −0.19)b

−1.14 (−1.80 to −0.73)

0.0618

 Weight gain, g/day

20 (16–24)b

20 (16–24)b

23 (14–26)b

21 (17–25)b

19 (14–23)b

0.4883

 Weight gain (2-point), g/kg/day

13 (10–14)b

13 (10–14)b

12 (10–14)b

12 (11–14)b

13 (12–14)b

0.6988

 Weight gain (Exponential), g/kg/day

13 (11–15)b

13 (10–15)b

12 (10–14)b

13 (12–15)b

14 (12–15)b

0.3648

 Length gain, cm/week

0.8 (0.6–1.0)b

0.8 (0.6–1.0)b

0.8 (0.3–1.0)b

0.8 (0.6–1.1)b

0.8 (0.6–1.0)b

0.8672

 Head Circumference gain, cm/week

0.7 (0.5–0.8)b

0.7 (0.5–0.8)b

0.6 (0.6–0.9)b

0.7 (0.6–0.8)b

0.7 (0.7–0.8)b

0.1434

  1. aMeasured at 36 weeks post-menstrual age (PMA) or discharge.
  2. bMedian (IQR).
  3. cMean ± SD.
  4. dCalculated between birth and 36 weeks PMA or discharge.
  5. Bold text denotes statistical significance p < 0.05.