Fig. 3: Prenatal T exposure induces sex-specific neurostructural deficits in offspring. | Pediatric Research

Fig. 3: Prenatal T exposure induces sex-specific neurostructural deficits in offspring.

From: Elevated maternal testosterone induces sex-specific neurodevelopmental changes and ASD-related behavioral phenotypes in rat offspring

Fig. 3

a Representative immunofluorescent images (scale bar: 50 Όm) and quantification of NeuN+ neuronal density in the prefrontal cortex of P9 male and female offspring. Male T-exposed offspring showed reduced NeuN+ cells compared to male controls (*p < 0.05). b Representative images (scale bar: 100 Όm) and quantification of MBP+ myelinated area in the corpus callosum. Female T-exposed offspring exhibited reduced myelination vs. female controls (*p < 0.05). Insets show a magnified area of the dotted box in the image. Data represent mean ± SD (n = 6 litters/group; two-way ANOVA with Tukey’s post hoc test).

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