Fig. 2: Whole blood transcriptome to confirm the effects of broad-spectrum antibiotics on immune and inflammation genes. | Pediatric Research

Fig. 2: Whole blood transcriptome to confirm the effects of broad-spectrum antibiotics on immune and inflammation genes.

From: Neonatal enteral antibiotics reduce gut inflammation and delay systemic immune development in preterm pigs

Fig. 2

a Whole blood Transcriptomics PCA scores plot of the first two principal components. The colored ellipses represent 95% confidence intervals for each group. b GSEA was performed between the AB and CON groups using the Sus scrofa (pig) KEGG knowledgebases. The top significant pathways ranked by FDR value have been selected for visualization. The size and color of the dots indicate the gene ratio and FDR values, respectively. The complete list of enriched pathways can be found in Table S3. c Volcano plots between AB and CON group. A threshold of FDR < 0.05 was set to illustrate the differentially expressed genes (DEGs). d–f Heatmap illustrating DEGs involved in the Toll-like receptor, TNF, and JAK-STAT signaling pathways between AB and CON groups. CON control, AB antibiotics, GSEA gene set enrichment analysis.

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