Fig. 1
From: Distinct transcriptional repertoire of the androgen receptor in ETS fusion-negative prostate cancer
AR-regulated genes discriminate tumors based on ETS status. An unsupervised PCA model of 101 AR-regulated genes affirms the distinct AR signatures of ETS+ and the ETS− samples in the first principal component for the TCGA RNA-seq (a) and in the second principal component for the GRID microarray profiling (b) PCa datasets. c and d show the relative contribution of the individual AR-regulated genes to the PCA models in a and b, respectively. The t-SNE model shows similar results to the PCA model for the TCGA (e) and the GRID (f) dataset, where there is a clear separation between the ETS− and ETS+ samples. The results also indicate that the molecular subtypes used for ETS+ (1-ERG, 2-ETV1, 3-ETV4, 4-FLI1) and ETS− (5-SPOP, 6-FOXA1, 7-IDH1, 8-other) fall into the correct ETS category
