Table 4 Showing the significant single SNP association for the development of prostate cancer and nearby genes in SELECT trial

From: Germline genetic variation in prostate susceptibility does not predict outcomes in the chemoprevention trials PCPT and SELECT

Trial arm

CHR

SNP

P

OR

Nearest gene

Placebo

1

rs636291

0.003377

0.6929

PEX14

Placebo

2

rs3771570

0.02715

1.404

FARP2

Placebo

6

rs4713266

0.01558

0.7583

TNS3

Placebo

8

rs1512268

0.05006

1.252

NKX3.1

Placebo

10

rs2252004

0.04196

0.683

N/A

Placebo

11

rs11214775

0.02261

0.7473

HTR3B

Placebo

12

rs1270884

0.04148

0.7919

TBX5

Placebo

17

rs1859962

0.002107

1.422

N/A

Placebo

23

rs5919432

0.006584

1.712

AR

Selenium

2

rs12621278

0.0256

0.563

ITGA6

Selenium

5

rs2242652

0.05695

0.7398

TERT

Selenium

8

rs2928679

0.04767

1.268

SLC25A37

Selenium

10

rs10993994

0.01418

1.345

MSMB

Selenium

10

rs2252004

0.05719

1.465

N/A

Selenium

11

rs1938781

0.0172

0.699

FAM111A

Selenium

12

rs80130819

0.03519

0.6222

N/A

Selenium

17

rs1859962

0.04747

1.267

N/A

Selenium

20

rs6062509

0.01023

0.7144

ZGPAT

Vit E

3

rs2660753

0.00565

1.659

N/A

Vit E

4

rs7679673

0.01517

0.7443

TET2

Vit E

6

rs2273669

0.04909

1.383

ARMC2, SESN1

Vit E

8

rs1512268

0.04919

1.261

NKX3.1

Vit E

10

rs10993994

0.03971

1.28

MSMB

Vit E

11

rs11214775

0.001709

0.661

HTR3B

Vit E

11

rs1938781

0.02891

0.7233

FAM111A

Vit E

11

rs7127900

0.03343

1.365

N/A

Vit E

11

rs7931342

0.03694

0.7825

N/A

Vit E

17

rs138213197

0.05212

3.532

N/A

Sel + Vit E

2

rs12621278

0.01127

0.5422

ITGA6

Sel + Vit E

2

rs10187424

0.03605

1.264

GGCX/VAMP8

Sel + Vit E

2

rs11902236

0.0422

1.275

TAF1B:GRHL1

Sel + Vit E

8

rs1447295

0.0118

1.556

N/A

Sel + Vit E

8

rs620861

0.01228

0.7508

N/A

Sel + Vit E

8

rs12543663

0.04453

1.273

N/A

Sel + Vit E

9

rs1571801

0.02191

0.7455

DAB21P (aggressive SNP)

Sel + Vit E

11

rs11568818

0.01959

0.7711

MMP7

Sel + Vit E

14

rs8014671

0.05637

1.237

N/A

Sel + Vit E

17

rs1859962

0.05754

1.234

N/A

Sel + Vit E

20

rs2427345

0.05815

0.8051

GATAS, CABLES2

Sel + Vit E

23

rs5945619

0.000263

1.808

NUDT11

Sel + Vit E

23

rs2405942

0.0367

0.6727

SHROOM2

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