Fig. 4: Decision curve analysis for the diagnostic strategies for the detection of high-grade PCa.

Decision curve analysis for the detection of high-grade PCa of the SelectMDx-test-only, mpMRI-only, and with a positive SelectMDx test and/or suspicious mpMRI. Decision curve analysis using threshold probabilities ranging from 5 to 20% for the four diagnostic strategies. The strategy with the highest net benefit regarding high-grade PCa at a specific threshold probability is clinically most useful.