Fig. 1: MRI-calculated prostate volume and PSAD trends over time. | Prostate Cancer and Prostatic Diseases

Fig. 1: MRI-calculated prostate volume and PSAD trends over time.

From: Mapping PSA density to outcome of MRI-based active surveillance for prostate cancer through joint longitudinal-survival models

Fig. 1

a Prostate volume. Volumes were calculated using the ellipsoid formula. There was a steady increase in mean prostate volume over time (spline curve shown), at an approximate average rate of 3.3 mL/year. b PSA. There was a steady increase in mean PSA (spline curve shown). c, d PSAD trends stratified by Gleason and MRI visibility. PSAD was higher at baseline and throughout surveillance in men with Gleason 3 + 4 and MRI-visible disease. e PSAD trends stratified by censoring status. PSAD in men who ultimately experienced an event was consistently elevated throughout AS compared to men who were censored. The downward trend in the latter years is likely due to the drop-out of men with higher PSAD who experience events as time progresses.

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