Table 3 Presentation of the pooled incidence rates of infectious complications following transperineal prostate biopsy in groups with versus without periprocedural antibiotic prophylaxis (PAP) derived from all systematic reviews currently available.
Criteria | Basourakos [9] | Castellani [10] | Our own systematic review |
|---|---|---|---|
Methodology of the systematic review | Indirect comparison of study results | Direct comparison of study results | Direct comparison of study results |
Completion date of the literature search | 29-Dec-2020 | 02-Jun-2021 | 01-Jan-2024 |
Number of included studies | 106 | 8 | 23 |
Number of included studies with a prospective-randomized designa | Not applicable | 0 | 2 |
Number of patients with PAP | 37,805 | 2368 | 6520 |
Number of patients without PAP | 4772 | 1294 | 5804 |
Genitourinary tract infections (with vs. without PAP) | 1.35% (403/29,880) vs. 1.22% (58/4772), p = 0.494b | 0.13% (3/2368) vs. 0.31% (4/1294), p = 0.252b | 0.37% (20/5417) vs. 0.50% (27/5385), p = 0.297 |
Fever (with vs. without PAP) | Not reported | 0.69% (5/725) vs. 0.47% (4/846), p = 0.740b | 0.26% (9/3496) vs. 0.44% (10/2251), p = 0.228 |
Sepsis (with vs. without PAP) | 0.05% (19/37,805) vs. 0.08% (4/4772), p = 0.318b | 0.13% (3/2368) vs. 0.08% (1/1294), p = 0.999b | 0.13% (6/4655) vs. 0.16% (7/4249), p = 0.658 |
Readmission rate (with vs. without PAP) | Not reported | 0.13% (3/2368) vs. 0.23% (3/1294), p = 0.433b | 0.29% (14/4772) vs. 0.35% (18/5160), p = 0.626 |
30-day mortality (with vs. without PAP) | Not reported | Each 0% | Each 0% |
