Table 2 Comparison of active surveillance versus radical prostatectomy (A) or versus any local treatment (prostatectomy or radiotherapy) in relation to different domains of HRQoL measures.
Active surveillance vs radical prostatectomy (A) | Active surveillance vs any local treatment (B) | |||||
|---|---|---|---|---|---|---|
Domain A: general health-related quality of life (HRQOL) a | β | 95% CI | p | β | 95% CI | p |
EORTC QLQ-C30: global health status | 1.61 | −0.60; 3.82 | 0.154 | −0.26 | −3.74; 3.22 | 0.882 |
EORTC QLQ-C30: physical functioning | −0.47 | −1.47; 0.53 | 0.359 | −0.46 | −1.24; 0.32 | 0.246 |
EORTC QLQ-C30: role functioning | −0.68 | −1.83; 0.46 | 0.242 | −0.85 | −1.96; 0.27 | 0.136 |
EORTC QLQ-C30: emotional functioning | −0.35 | −1.30; 0.60 | 0.469 | −1.19 | −2.96; 0.58 | 0.187 |
EORTC QLQ-C30: social functioning | −0.18 | −3.12; 2.75 | 0.903 | −0.37 | −2.83; 2.08 | 0.765 |
EORTC QLQ-C30: cognitive functioning | −0.80 | −2.17; 0.56 | 0.248 | −1.51 | −3.05; 0.02 | 0.054 |
Domain B: anxiety and depressiona | ||||||
HADS: anxiety score | 0.22 | −0.08; 0.51 | 0.150 | 0.47 | −0.16; 1.10 | 0.147 |
HADS: depression score | 0.16 | −0.01; 0.33 | 0.051 | 0.36 | 0.13; 0.60 | 0.002 |
Domain C: sexual functioninga | ||||||
PR25: sexual function | 8.27 | 5.57; 10.96 | <.001 | 6.30 | 2.58; 10.03 | 0.001 |
PR25: sexual activity | 6.70 | 4.19; 9.20 | <.001 | 5.61 | 3.38; 7.84 | <0.001 |
IIEF: erectile function | 3.74 | 1.99; 5.49 | <.001 | 2.53 | 0.34; 4.71 | 0.023 |
Domain D: urinary/prostatic symptoms and bowel functionb | OR | 95%CI | p | OR | 95% CI | p |
PR25-Use of incontinence aids | 0.14 | 0.09; 0.23 | <.001 | 0.21 | 0,13; 0,33 | <0.001 |
IPSS-presence of moderate/severe prostatic symptoms | 2.77 | 1.52; 5.06 | 0.001 | 2.15 | 1.29; 3.59 | 0.003 |
PR25-presence of bowel symptoms | 1.24 | 0.72; 2.12 | 0.439 | 0.97 | 0.57; 1.69 | 0.960 |