Table 2 Comparison of active surveillance versus radical prostatectomy (A) or versus any local treatment (prostatectomy or radiotherapy) in relation to different domains of HRQoL measures.

From: Quality of life in low-risk prostate cancer under active surveillance or following radical treatments: the START cohort study

 

Active surveillance vs radical prostatectomy (A)

Active surveillance vs any local treatment (B)

Domain A: general health-related quality of life (HRQOL) a

β

95% CI

p

β

95% CI

p

 EORTC QLQ-C30: global health status

1.61

−0.60; 3.82

0.154

−0.26

−3.74; 3.22

0.882

 EORTC QLQ-C30: physical functioning

−0.47

−1.47; 0.53

0.359

−0.46

−1.24; 0.32

0.246

 EORTC QLQ-C30: role functioning

−0.68

−1.83; 0.46

0.242

−0.85

−1.96; 0.27

0.136

 EORTC QLQ-C30: emotional functioning

−0.35

−1.30; 0.60

0.469

−1.19

−2.96; 0.58

0.187

 EORTC QLQ-C30: social functioning

−0.18

−3.12; 2.75

0.903

−0.37

−2.83; 2.08

0.765

 EORTC QLQ-C30: cognitive functioning

−0.80

−2.17; 0.56

0.248

−1.51

−3.05; 0.02

0.054

Domain B: anxiety and depressiona

 HADS: anxiety score

0.22

−0.08; 0.51

0.150

0.47

−0.16; 1.10

0.147

 HADS: depression score

0.16

−0.01; 0.33

0.051

0.36

0.13; 0.60

0.002

Domain C: sexual functioninga

 PR25: sexual function

8.27

5.57; 10.96

<.001

6.30

2.58; 10.03

0.001

 PR25: sexual activity

6.70

4.19; 9.20

<.001

5.61

3.38; 7.84

<0.001

 IIEF: erectile function

3.74

1.99; 5.49

<.001

2.53

0.34; 4.71

0.023

Domain D: urinary/prostatic symptoms and bowel functionb

OR

95%CI

p

OR

95% CI

p

 PR25-Use of incontinence aids

0.14

0.09; 0.23

<.001

0.21

0,13; 0,33

<0.001

 IPSS-presence of moderate/severe prostatic symptoms

2.77

1.52; 5.06

0.001

2.15

1.29; 3.59

0.003

 PR25-presence of bowel symptoms

1.24

0.72; 2.12

0.439

0.97

0.57; 1.69

0.960

  1. All models are adjusted for age, education, presence of partner, PSA, Gleason score, tumour stage, Charlson comorbidity index and PROM values at baseline.
  2. aRegression coefficients (β).
  3. bLogistic regression odds ratios (OR).