Fig. 3
From: The intracellular signalosome of PD-L1 in cancer cells
The PD-L1 interactome in human cells. The human PD-L1 interactome was obtained by high-throughput affinity-purification mass spectrometry performed on human 293T cells.91 STRING analysis was performed by introducing all the proteins from the interactome (supplementary figure 1) as inputs in STRING (https://string-db.org/) and selecting the Homo sapiens database to detect interactions with a medium confidence of 0.7. The STRING output classified the proteins into four functional groups, a “signalosome” group (a), a nuclear import/export group (b), a mRNA import/export interactome group (c) and a Golgi-ER interactome group (d). The most relevant interactomes are (a) and (d) according to PD-L1 functions and processing in the Golgi-ER. The relationships between proteins are indicated within the graph as action types and action effects
