Fig. 4

Potential Crosstalk between the interferon signaling pathway and PD-L1 signalosome. STRING analysis of the core mediators of IFN signal transduction. STRING analysis was performed by introducing all the proteins from the interactome (supplementary figure 1 and supplementary Tables 1) together with key regulators of IFN signal transduction (IFNAR1, STAT1, STAT2, STAT3, JAK1, JAK2) and mediators of apoptosis (CASP3, CASP7, CASP9) as inputs (https://string-db.org/) and selecting the Homo sapiens database to detect interactions with a medium confidence of 0.7. According to the functional interactome provided by STRING based on known published molecular interactions, mTOR/AKT plays a central regulatory role coordinating the inhibition of caspases via AKT and its interactions with STATs. Importantly, mTOR/AKT associates and integrates signals from DNA damage response kinases with regulators of Ras signaling, PI4K and c-myc. The relationships between proteins are indicated within the graph as action types and action effects