Fig. 5 | Signal Transduction and Targeted Therapy

Fig. 5

From: RNA-binding protein LIN28B inhibits apoptosis through regulation of the AKT2/FOXO3A/BIM axis in ovarian cancer cells

Fig. 5

The protein expression level of AKT2 is regulated by LIN28B. a Detection of the binding of LIN28B to AKT2 and BIM mRNA using RNA-IP followed by q-PCR assay in A2780 and TOV-112D cells. Bar graphs show representative results of relative mRNA enrichment of AKT2 and BIM from three independent experiments. *p < 0.05. b The expression changes in total and phospho-AKT2 and total and phospho-FOXO3A upon LIN28B knockdown was detected by western blotting in A2780 and TOV-112D cells. c The mRNA level change in AKT2upon LIN28B knockdown (A2780) or overexpression (TOV-112D) was quantified by q-PCR. The results show the representative image from three independent experiments

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