Fig. 2 | Signal Transduction and Targeted Therapy

Fig. 2

From: Targeted chemotherapy for subcutaneous and orthotopic non-small cell lung tumors with cyclic RGD-functionalized and disulfide-crosslinked polymersomal doxorubicin

Fig. 2

a Cytotoxicity of blank cRGD-PS to A549 cells following 48 h incubation. b Viability of A549 cells after a 4 h incubation with cRGD-PS-Dox plus 44 h culture in fresh media. c Flow cytometry of A549 cells after a 4 h incubation with different formulations (10.0 μg/mL Dox·HCl). d CLSM of A549 cells treated with different formulations for 4 h (10.0 μg/mL Dox·HCl) and further cultured in fresh media for 4 h. The cell nuclei and cytoskeleton were stained by DAPI and phalloidin-FITC, respectively. Scale bars: 25 μm

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