Fig. 3 | Signal Transduction and Targeted Therapy

Fig. 3

From: Targeted chemotherapy for subcutaneous and orthotopic non-small cell lung tumors with cyclic RGD-functionalized and disulfide-crosslinked polymersomal doxorubicin

Fig. 3

a In vivo pharmacokinetics of cRGD-PS-Dox, PS-Dox and Lipo-Dox in tumor-free mice. b In vivo fluorescence images of mice bearing subcutaneous A549 tumors after iv injection of Cy7-labeled cRGD-PS or PS. c Ex vivo fluorescence images of tumors and major organs isolated at 12 h post-injection. d Quantitative drug biodistribution in tumors and major organs. *p < 0.05 based on one-way ANOVA and Tukey multiple comparisons tests. For a and d, the Dox·HCl concentration was measured by fluorescence spectroscopy and are presented as the mean ± SD (n = 3)

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