Fig. 4 | Signal Transduction and Targeted Therapy

Fig. 4

From: Targeted chemotherapy for subcutaneous and orthotopic non-small cell lung tumors with cyclic RGD-functionalized and disulfide-crosslinked polymersomal doxorubicin

Fig. 4

Antitumor activity of cRGD-PS-Dox and PS-Dox in nude mice bearing subcutaneous A549 tumors. The drug was given on day 0, 4, 8, and 12 (Dox dose: 6 or 12 mg/kg, in 200 µL PBS). Lipo-Dox and PBS were used as controls. a Tumor volumes over 20 days. b Body weight changes over 20 d. c Photographs of tumor blocks collected on day 20. d Tumor inhibition rate on day 20. *p < 0.05, **p < 0.01 and ***p < 0.001 based on one-way ANOVA and Tukey multiple comparisons tests

Back to article page