Fig. 6
From: miR-23a promotes invasion of glioblastoma via HOXD10-regulated glial-mesenchymal transition
Mechanisms of miR-23a-regulated promotion of GBM invasion through targeting of HOXD10. a, b KMG4 cells were transfected with anti-miR-23a and scramble DNA as a control, and the expression levels of Snail, MMP2, MMP9, and MMP14 (a) and invasion ability (b) were investigated. *P < 0.05, **P < 0.005, and ***P < 0.0005 vs. the indicated samples. c miR-23a directly targets the HOXD10-3′-UTR, triggering dramatic alterations in the expression of genes associated with invasion (uPAR, MMP14, RhoA, and RhoC) and glial-mesenchymal transition (GMT) events (Snail, Slug, MMP2, MMP9, and E-cadherin), and inducing polarity of focal adhesions, ultimately resulting in cooperatively aggressive invasion of GBM
