Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: Targeting growth hormone function: strategies and therapeutic applications

Fig. 1

Endocrine regulation of GH and therapeutic blockade. GH is secreted from the anterior pituitary under the control of hypothalamic hormones, growth hormone releasing hormone (GHRH) and somatostatin (SSTN), and ghrelin, which is predominantly secreted in the stomach. Endocrine secretion of GH impacts numerous physiological systems with wide-ranging effects in various tissues. GH is also expressed in extrapituitary tissues in which it has localized autocrine/paracrine effects. Strategies to antagonize GH signaling are shown and are described in detail below

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